Cell Fractionation guinea pig pancreas rough microsomes

Creator:

Palade, George E
Siekevitz, Philip

Published/Created:

New Haven, CT
Yale University School of Medicine
2/2/1967

Physical Description:

3.25 in. x 4 in.

Related Links:

http://jcb.rupress.org/content/4/3/309.abstract
http://jcb.rupress.org/content/2/6/671.abstract
http://jcb.rupress.org/content/1/1/59.abstract
http://www.jbc.org/content/241/5/1150.abstract
http://jcb.rupress.org/content/45/1/146.abstract

Notes:

3.25 in. x 4 in. Lantern Slides
Original Magnification: x54,000
Rough microsomes, the cell fractionation equivalent of the rough ER in intact cells, were extensively used to determine the mechanism of translocation of newly synthesized exportable proteins across the ER membrane. The culmination of these studies on rough microsomes was the elucidation of the "Signal Hypothesis".

Topics:

Cell Fractionation

Topics:

Jamieson, James D

Genre:

transmission electron micrograph

Format:

Image

Content Type:

Prints & Photographs

Rights:

The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement
Yale Community Only

Access Restrictions:

Public

Yale Collection:

Cushing/Whitney Medical Library

Digital Collection:

George E. Palade Electron Microscopy Slide Collection

Citation:

See See Siekevitz, P. and G. E. Palade.1958. A cytochemical study on the pancreas of the guinea pig. II. Functional variations in the enzymatic activity of microsomes. J. Biochem. Biophys. Cytol. 4:309-318.
Palade, G.E., and P. Siekevitz. 1956. Pancreatic microsomes. An integrated morphological and biochemical study. J. Biochem. Biophys. Cytol. 2:671-690.
Palade. G.E. 1955. A small particulate component of the cytoplasm. J. Biochem. Biophys. Cytol. 1:59-68.
Redman, C.M., P. Siekevitz, and G.E. Palade. 1966. Synthesis and transfer of amylase in pigeon pancreatic ribosomes. J. Biol. Chem. 241:1150-1158.
Sabatini, D.D. and G. Blobel. 1970. Controlled proteolysis of nascent polypeptides in rat liver cell fractions: Location of the polypeptides in rough microsomes. J. Cell. Biol. 45:146-157.

OID:

15817829

PID:

digcoll:2795279