Mitochondria Guinea Pig Pancreas lipid droplets
- Creator:
- Palade, George E
- Published/Created:
- New Haven, CT
Yale University School of Medicine
3/12/1962 - Physical Description:
- 3.25 in. x 4 in.
- Notes:
- 3.25 in. x 4 in. Lantern Slides
Original Magnification: x12,100
The use of osmium tetroxide as a fixative for electron microscopy was first described by Dr. Palade at the Rockefeller. Another major advance in fixation for electron microscopy was done at Yale by David Sabatini who described the use of glutaraldehyde which not only preserved ultrastructure, but enzymatic activities which opened up the possibility of EM localization of enzymatic function in cells. Dr. Sabatini later joined the laboratory of Dr. Palade at the Rockefeller where he carried out his PhD studies on ribosomes and their relationship to the ER membrane during synthesis of exportable proteins. - Topics:
- Mitochondria
- Topics:
- Jamieson, James D
- Genre:
- transmission electron micrograph
- Format:
- Image
- Content Type:
- Prints & Photographs
- Rights:
- The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement
Yale Community Only - Access Restrictions:
- Public
- Yale Collection:
- Cushing/Whitney Medical Library
- Digital Collection:
- George E. Palade Electron Microscopy Slide Collection
- Citation:
- See Palade, G.E. 1952. A study of fixation for electron microscopy. J. Exp. Med. 95:285-298.
Palade, G.E. 1952. The fine structure of mitochondria. Anat. Rec. 114:427-451.
Sabatini, D.D, K. Bensch and R.J. Barrnett. 1963. Cytochemistry and electron microscopy: The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J. Cell. Bio. 17:19-58. - OID:
- 15817934
- PID:
- digcoll:2795362
